GRANULOCYTIC SARCOMA FOLLOWING ACUTE MYELOGENOUS LEUKEMIA TYPE FAB-M5 ASSOCIATED WITH t(6;12) INVOLVING A REARRANGEMENT OF THE ETV6 LOCUS
نویسندگان
چکیده
Background : Acute myelogenous leukemia is a cancer that affects myeloid cells. Several complications occur due to acute myelogenous leukemia of which is granulocytic sarcoma. This case report discusses the analysis of skin abnormalities in an acute myelogenous leukemia patient. Case description : Skin examination and fine needle aspiration of the nodules in comparison with previous bone marrow biopsy confirmed the diagnosis of myeloid sarcoma. Cytogenetic analysis showed t(6;12) involving a rearrangement of the ETV6 locus. Conclusions : This is a unique report of a case of granulocytic sarcoma following acute myelogenous leukemia type 5 with t(6;12) involving a rearrangement of the ETV6 locus. Several precautions should be made in diagnosing such conditions. A combination of systemic chemotherapy and local electron-beam therapy or PUVA to treat chemotherapy resistant leukemia cutis lesions is needed.
منابع مشابه
Granulocytic Sarcoma Presenting as Subconjunctival Mass
Chloroma or granulocytic sarcoma (GS) is a malignant neoplasm of myeloid lineage that occur in a variety of anatomic sites other than the bone marrow including soft tissue, bone, lymph node, nasal fossa, skin and sometime in the orbit. In the subconjunctiva it is rarely reported. A 4-year-old girl with a history of treated acute myelogenous leukemia was referred to Farabi Eye Hospital, Tehra...
متن کاملAcute Erythroblastic Leukemia (AEL): A Rare Subset of De Novo AML with A Complex Rearrangement Involving ETV6 Locus and Loss of RB1 Locus
Int Clin Pathol J 2016, 2(2): 00032 locus has been identified in children of age two years or younger with various types of leukemia. Heterogeneity of the breakpoints ranging from 7q32 (very few) or q36 (frequently) and 12p13 have been reported in myeloid disorders [4-9]. We report here a case of Pediatric Acute Erythroblastic Leukemia with a variant t(7;12) translocation involving three chromo...
متن کاملFusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13).
The ETV6 gene (also known as TEL) is the main target of chromosomal translocations affecting chromosome band 12p13. The rearrangements fuse ETV6 to a wide variety of partner genes in both myeloid and lymphoid malignancies. We report here 4 new cases of acute myeloid leukemia (AML) with very immature myeloblasts (French-American-British [FAB]-M0) and with a t(4;12)(q11-q12;p13). In all cases, ET...
متن کاملCharacterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia
BACKGROUND Characterization of novel fusion genes in acute leukemia is important for gaining information about leukemia genesis. We describe the characterization of a new ETV6 fusion gene in acute myeloid leukemia (AML) FAB M0 as a result of an uncommon translocation involving chromosomes 12 and 15. METHODS The ETV6 locus at 12p13 was shown to be translocated and to constitute the 5' end of t...
متن کاملFacial nerve paralysis in acute otomastoiditis as presenting symptom of FAB M2, T8;21 leukemic relapse. Case report and review of the literature.
Granulocytic sarcoma (chloroma) is a rare solid, extramedullary tumour composed of immature granulocytes, occurring during granulocytic leukemia. Leukemic involvement of the temporal bone is not uncommon and may present in a variety of ways. Symptomatic facial nerve paralysis is one of these. The authors report a case of facial nerve paralysis as the presenting symptom of leukemic relapse in a ...
متن کامل